{"id":6287,"date":"2026-10-05T16:46:20","date_gmt":"2026-10-05T14:46:20","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=6287"},"modified":"2026-10-05T16:46:20","modified_gmt":"2026-10-05T14:46:20","slug":"50-long-term-complications-after-total-body-irradiation-in-children-younger-than-4-years-transplanted-for-acute-lymphoblastic-leukemia-bone-marrow-transplant","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/50-long-term-complications-after-total-body-irradiation-in-children-younger-than-4-years-transplanted-for-acute-lymphoblastic-leukemia-bone-marrow-transplant\/","title":{"rendered":"50. Long-term complications after total body irradiation in children younger than 4 years transplanted for acute lymphoblastic leukemia. Bone Marrow Transplant."},"content":{"rendered":"<h3>Neven Q, Berbis J, Michel G, Domenech C, Pochon C, Visentin S, Renard C, Baruchel A, Fahd M, Gandemer V, Poir\u00e9e M, Jubert C, Ducassou S, Paillard C, Olivier-Gougenheim L, Theron A, Armari-Alla C, Kanold J, Thouvenin-Doulet S, Veneziano Broccia M, Thomas C, Tabone MD, Leverger G, Auquier P, Dalle JH, Saultier P.<\/h3>\n<p>&nbsp;<\/p>\n<p>Bone Marrow Transplant. 2026 Aug 20<\/p>\n<p>doi: 10.1038\/s41409-026-03014-9. Epub ahead of print. PMID: 42624967<\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<p>Total body irradiation (TBI)-based conditioning is the standard regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in high-risk or relapsed pediatric acute lymphoblastic leukemia (ALL), but is variably used before age 4 because of concerns about long-term toxicity. Long-term physical, educational, and quality-of-life outcomes were assessed in patients from the French long-term follow-up program LEA who underwent TBI-based HSCT for ALL at 2 to &lt;4 years of age (younger group, n = 37) and compared with those of matched prepubertal older children transplanted at \u22654 years (older group, n = 105). After a mean follow-up of 15.6 years, the number of complications was similar in the two groups (3.3 vs 3.2, p = 0.90). Among the 20 complications analyzed, pulmonary dysfunction was the only event that differed significantly, being more frequent in the older group (43% vs 19%, p = 0.01). In a multivariate multistate model, age group was not associated with a higher risk of transition to a greater complication burden (HR 1.05, 95% CI 0.83-1.32; p = 0.70). Educational outcomes and quality of life were also comparable. These findings do not suggest greater long-term toxicity in children undergoing TBI-based HSCT at 2 to &lt;4 years of age and support reconsideration of the lower age limit for its use.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neven Q, Berbis J, Michel G, Domenech C, Pochon C, Visentin S, Renard C, Baruchel A, Fahd M, Gandemer V, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[],"class_list":["post-6287","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>50. Long-term complications after total body irradiation in children younger than 4 years transplanted for acute lymphoblastic leukemia. Bone Marrow Transplant. - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/50-long-term-complications-after-total-body-irradiation-in-children-younger-than-4-years-transplanted-for-acute-lymphoblastic-leukemia-bone-marrow-transplant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"50. Long-term complications after total body irradiation in children younger than 4 years transplanted for acute lymphoblastic leukemia. 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