{"id":6278,"date":"2026-10-05T16:27:17","date_gmt":"2026-10-05T14:27:17","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=6278"},"modified":"2026-10-05T16:36:30","modified_gmt":"2026-10-05T14:36:30","slug":"48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/","title":{"rendered":"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort"},"content":{"rendered":"<h3>Capitaine AG, Mustafa-Shawket A, Berbis J, Felizardo R, Dalle JH, Auquier P, Bouayad L, Petit A, Leverger G, Michel G, Tabone MD.<\/h3>\n<p>&nbsp;<\/p>\n<p>Arch Pediatr. 2026 Jul;33(5):105544.<\/p>\n<p>doi: 10.1016\/j.arcped.2026.105544. Epub 2026 May 20. PMID: 42161079.<\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<p><strong class=\"sub-title\">Background: <\/strong>Oral abnormalities resulting from childhood leukemia treatment may significantly impact long-term health outcomes.<\/p>\n<p><strong class=\"sub-title\">Objectives: <\/strong>This prospective study aims to evaluate oral health, to assess oral health-related quality of life (OHRQoL) among leukemia survivors, its impact on general Health Related Quality of Life (HRQoL) and to identify risk factors for oral health impairments.<\/p>\n<p><strong class=\"sub-title\">Methods: <\/strong>Dental examination was proposed to patients included in the LEA cohort (long-term follow-up of childhood\/adolescent leukemia survivors) in two pediatric hematology centers. For cavities, Decayed\/Missing\/Filled\/Teeth (DMFT\/dmft) index was determined. Quantitative and qualitative saliva analyses were performed. Orthopantomograms were independently reviewed. OHRQoL was assessed using age-adapted questionnaires. Patient characteristics, treatment history, socio-economic status and HRQoL were extracted from LEA database. Statistical analyses were performed using SPSS software. Pearson&#8217;s Chi2\/Fisher&#8217;s exact test\/Student&#8217;s t-test\/Spearman correlation test\/Adjusted multivariate logistic regression model were used when appropriate.<\/p>\n<p><strong class=\"sub-title\">Results: <\/strong>Eighty-nine patients were included with a mean follow-up from diagnosis of 12.5 \u00b1 0.8 years. Females represented 48% of the cohort, acute lymphoblastic leukemia 76%. A history of leukemia relapse concerned 27% of patients; 45% of the cohort underwent hematopoietic stem cell transplantation (HSCT). Eighty-five patients had \u22651 oral abnormalities (excluding cavities); 53 required treatment intervention. Mean DMFT\/dmft index was 2.3 \u00b1 0.4; lower parents&#8217; education level was linked with higher index (p = 0.029). Younger age at diagnosis (&lt;6 years old) was associated with enamel defects (p = 0.001). History of relapse was associated with teeth number, morphology and eruption abnormalities (p &lt; 0.05). HSCT was associated with morphology abnormalities (p &lt; 0.05). Among transplanted patients, no significant impact of total body irradiation on oral abnormalities was found as compared to busulfan-based conditioning regimen. In children, altered OHRQoL tend to have a negative impact on body image and physical well-being.<\/p>\n<p><strong class=\"sub-title\">Conclusion: <\/strong>The high prevalence of oral abnormalities in pediatric leukemia survivors necessitates proactive dental monitoring and early interdisciplinary collaboration between pediatrician and dentists.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Capitaine AG, Mustafa-Shawket A, Berbis J, Felizardo R, Dalle JH, Auquier P, Bouayad L, Petit A, Leverger G, Michel G, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[],"class_list":["post-6278","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort - Lea\" \/>\n<meta property=\"og:description\" content=\"Capitaine AG, Mustafa-Shawket A, Berbis J, Felizardo R, Dalle JH, Auquier P, Bouayad L, Petit A, Leverger G, Michel G, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/\" \/>\n<meta property=\"og:site_name\" content=\"Lea\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-05T14:36:30+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/\",\"name\":\"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort - Lea\",\"isPartOf\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\"},\"datePublished\":\"2026-10-05T14:27:17+00:00\",\"dateModified\":\"2026-10-05T14:36:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/accueil\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientific publications\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"name\":\"Lea\",\"description\":\"Malignant haemopathies in children and adolescents\",\"publisher\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\",\"name\":\"Plateforme LEA\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"contentUrl\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"width\":600,\"height\":260,\"caption\":\"Plateforme LEA\"},\"image\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/","og_locale":"en_US","og_type":"article","og_title":"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort - Lea","og_description":"Capitaine AG, Mustafa-Shawket A, Berbis J, Felizardo R, Dalle JH, Auquier P, Bouayad L, Petit A, Leverger G, Michel G, [&hellip;]","og_url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/","og_site_name":"Lea","article_modified_time":"2026-10-05T14:36:30+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/","url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/","name":"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort - Lea","isPartOf":{"@id":"https:\/\/plateforme-lea.fr\/en\/#website"},"datePublished":"2026-10-05T14:27:17+00:00","dateModified":"2026-10-05T14:36:30+00:00","breadcrumb":{"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/48-increased-susceptibility-to-long-term-complications-in-leukemia-survivors-who-received-hematopoietic-stem-cell-transplantation-during-adolescence\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/plateforme-lea.fr\/en\/accueil\/"},{"@type":"ListItem","position":2,"name":"Scientific publications","item":"https:\/\/plateforme-lea.fr\/en\/publications_science\/"},{"@type":"ListItem","position":3,"name":"48. Evaluation of oral health and oral health-related quality of life among childhood leukemia survivors: a pilot study in the LEA cohort"}]},{"@type":"WebSite","@id":"https:\/\/plateforme-lea.fr\/en\/#website","url":"https:\/\/plateforme-lea.fr\/en\/","name":"Lea","description":"Malignant haemopathies in children and adolescents","publisher":{"@id":"https:\/\/plateforme-lea.fr\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/plateforme-lea.fr\/en\/#organization","name":"Plateforme LEA","url":"https:\/\/plateforme-lea.fr\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/","url":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","contentUrl":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","width":600,"height":260,"caption":"Plateforme LEA"},"image":{"@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/6278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science"}],"about":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/types\/publications_science"}],"version-history":[{"count":0,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/6278\/revisions"}],"wp:attachment":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/media?parent=6278"}],"wp:term":[{"taxonomy":"keywords","embeddable":true,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/keywords?post=6278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}