{"id":6155,"date":"2026-02-24T15:22:53","date_gmt":"2026-02-24T14:22:53","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=6155"},"modified":"2026-02-24T15:26:13","modified_gmt":"2026-02-24T14:26:13","slug":"43-long-term-kidney-complications-in-childhood-leukemia-survivors-a-study-from-the-childhood-and-adolescent-leukemia-lea-project","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/43-long-term-kidney-complications-in-childhood-leukemia-survivors-a-study-from-the-childhood-and-adolescent-leukemia-lea-project\/","title":{"rendered":"43. Long-term kidney complications in childhood leukemia survivors: a study from the Childhood and Adolescent Leukemia (LEA) project"},"content":{"rendered":"<h3>Carine Domenech, Pascal Saultier, Zeinab Hamidou, Marie-Dominique Tabone, Marl\u00e8ne Pasquet, Virginie Gandemer, St\u00e9phane Ducassou, Marilyne Poir\u00e9e, Dominique Plantaz, Jean-Hugues Dalle, Pascal Chastagner, Sandrine Thouvenin, Justyna Kanold, Alexandre Theron, Isabelle Pellier, Yves Reguerres, Andr\u00e9 Baruchel, Pascal Auquier, Justine Bacchetta, G\u00e9rard Michel, Laurence Derain-Dubourg<\/h3>\n<p>Haematologica. 2025 Sep 1;110(9):1987-1997. doi: 10.3324\/haematol.2024.286940. Epub 2025 Apr 3. PMID: 40176764; PMCID: PMC12399945.<\/p>\n<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/40176764\/<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>Acute leukemias represent the first cause of cancer in children. Their prognosis has improved significantly due to remarkable advances in therapeutic management, despite the risk of long-term consequences, especially for patients who underwent allogenic hematopoietic stem cell transplantation (aHSCT). Through the Leukemia in Children and Adolescents (LEA) long-term follow-up cohort (clinicaltrials gov. Identifier:\u00a0<a title=\"See in ClinicalTrials.gov\" href=\"http:\/\/clinicaltrials.gov\/show\/NCT01756599\">NCT01756599<\/a>), we conducted a French national multicenter prospective study on the occurrence and risk factors of chronic kidney disease (CKD), differentiating glomerular and tubular dysfunctions, corresponding to the NephroLEA project. Among the 1,676 patients included, the median age at evaluation was 15.8 (interquartile range [IQR], 11.3-20.5) years, with a median follow-up of 9.2 (IQR, 5.8-13.9) years. aHSCT was performed on 343 (20.6%) patients, half of whom have undergone the procedure after achieving second or greater remission. A higher percentage of children among transplanted patients had diastolic and systolic blood pressure above the 95th, with 13.7% versus 5.2% (P=3&#215;10-3) and 15% versus 6.5% (P=9&#215;10-2), respectively. A total of 187 patients (11.1%) had a mild CKD (i.e., eGFR between 75 and 90 mL\/min\/1.73 m2), while 3% (N=50) exhibited mild to severe CKD (eGFR &lt;75 mL\/min\/1.73 m2). Notably, no patient reached kidney failure. Twenty-one patients (1.3%) had decreased glomerular filtration rate associated with tubular impairment. The principal risk factors for developing CKD were aHSCT and leukemia relapse. In conclusion, CKD represents a long-term risk for patients who relapsed and\/or underwent aHSCT. These patients could benefit from nephroprotection advice to further improve their long-term outcomes, which is becoming a public health issue.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Carine Domenech, Pascal Saultier, Zeinab Hamidou, Marie-Dominique Tabone, Marl\u00e8ne Pasquet, Virginie Gandemer, St\u00e9phane Ducassou, Marilyne Poir\u00e9e, Dominique Plantaz, Jean-Hugues Dalle, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[],"class_list":["post-6155","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>43. 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