{"id":6144,"date":"2026-02-24T15:56:43","date_gmt":"2026-02-24T14:56:43","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=6144"},"modified":"2026-02-24T15:56:25","modified_gmt":"2026-02-24T14:56:25","slug":"45-genomics-of-long-term-complications-of-childhood-leukemia-rationale-and-design-of-the-genlea-study","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/45-genomics-of-long-term-complications-of-childhood-leukemia-rationale-and-design-of-the-genlea-study\/","title":{"rendered":"45. Genomics of Long-Term Complications of Childhood Leukemia : Rationale and Design of the GenLEA Study"},"content":{"rendered":"<h3>Mathilde Veneziano-Broccia, G\u00e9rard Michel, Jean-Hugues Dalle, Jean-Fran\u00e7ois Deleuze, Robert Olaso, Ga\u00eblle Munsch, Marine Germain, Caroline Meguerditchian, St\u00e9phane Ducassou, Carine Domenech, Marie-Dominique Tabone, Pascal Auquier, Julie Berbis, David-Alexandre Tregouet, Paul Saultier<\/h3>\n<p>Pediatr Blood Cancer. 2026 Jan 4:e70027. doi: 10.1002\/1545-5017.70027. PMID: 41486745.<\/p>\n<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/41486745\/<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Survivors of childhood acute leukemia are at risk of long-term treatment-related complications, but the role of genetic susceptibility remains unclear. We describe here the GenLEA project, which was established to investigate genetic determinants of long-term complications.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>GenLEA builds on the French LEA cohort, which prospectively follows acute leukemia survivors since 2004 through standardized dedicated consultations every 2 to 4 years. Patients were selected from the nested CryoLEA biobank. Cases were defined as survivors with at least one of four major complications (anthracycline-related cardiomyopathy, secondary malignant neoplasms, metabolic syndrome, or osteonecrosis) while controls were survivors without these complications, selected with the objective of a 1:3 case-to-control ratio. Genetic data were generated using genome-wide genotyping and whole-exome sequencing.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>After quality control, 743 patients were included for analyses (241 cases and 502 controls). Fifty-one percent were male with a median age at diagnosis of 7.3 years (IQR 3.9-13.0), and median follow-up reached 14 years (IQR 7.9-19.8). Among the cases, 44 had cardiomyopathy, 50 osteonecrosis, 37 secondary malignant neoplasms, and 163 metabolic syndrome. Planned analyses include genome-wide association studies (GWAS) and downstream analyses such as transcriptome-wide association studies (TWAS) and Mendelian randomization on genotyping data, as well as gene-based tests on exome sequencing data.<\/p>\n<p><strong class=\"sub-title\">Perspectives:\u00a0<\/strong>By integrating these approaches with high-quality clinical information, GenLEA offers a unique opportunity to identify molecular determinants of late complications after childhood acute leukemia. This collaborative resource will support replication efforts, meta-analyses, and ultimately the development of personalized long-term follow-up strategies.<\/p>\n<\/div>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>acute leukemia; genomics; long\u2010term complications.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Mathilde Veneziano-Broccia, G\u00e9rard Michel, Jean-Hugues Dalle, Jean-Fran\u00e7ois Deleuze, Robert Olaso, Ga\u00eblle Munsch, Marine Germain, Caroline Meguerditchian, St\u00e9phane Ducassou, Carine Domenech, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[],"class_list":["post-6144","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>45. Genomics of Long-Term Complications of Childhood Leukemia : Rationale and Design of the GenLEA Study - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/45-genomics-of-long-term-complications-of-childhood-leukemia-rationale-and-design-of-the-genlea-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"45. 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