{"id":5534,"date":"2023-09-12T16:41:49","date_gmt":"2023-09-12T14:41:49","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=5534"},"modified":"2023-09-12T16:41:49","modified_gmt":"2023-09-12T14:41:49","slug":"35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/","title":{"rendered":"35. Brothers and sisters of childhood acute leukemia survivors: Their long-term quality of life and its determinants"},"content":{"rendered":"<h3><span class=\"authors-list-item \">Cindy Faust<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Pascal Auquier<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Zeinab Hamidou<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Yves Bertrand<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Marie-Dominique Tabone<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Sophie Ansoborlo<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Andr\u00e9 Baruchel<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Virginie Gandemer<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Jean-Hugues Dalle<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Pascal Chastagner<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Justyna Kanold<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Maryline Poir\u00e9e<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Nicolas Sirvent<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Genevi\u00e8ve Plat<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Isabelle Pellier<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">G\u00e9rard Michel <span class=\"comma\">, <\/span><\/span><span class=\"authors-list-item \">Julie Berbis<\/span><\/h3>\n<p><a href=\"http:\/\/Cancer Medicine\">Cancer Medicine<\/a>. 2023 Mar;12(5):6200-6212<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36266927\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36266927\/<\/a><\/p>\n<p><strong>Background<\/strong>: Childhood cancer confront the whole family with a traumatic event. Because brothers and sisters may encounter emotional problems that can remain for a long time and that only few studies have assessed their long-term outcome, our present objectives were to describe the long-term quality of life (QoL) of childhood leukemia survivors&#8217; siblings and to explore its determinant. <strong>Methods<\/strong>: Brothers and sisters (from 8-year-old) of survivors included in the French LEA Cohort completed a QoL questionnaire (according to their age). Scores were compared with those reported by age- and gender-matched French general population and by survivors. Using a clustering method, siblings were categorized into 3 groups depending on their level of QoL&#8217;s scores and factors likely to be linked with these clusters were explored with multivariate analyses. <strong>Results<\/strong>: We included 689 brothers and sisters (313 minors, 376 adults) and the mean time from diagnosis was 13.2 \u00b1 6.6 years. Minor siblings reported higher QoL scores than general population (p &lt; 0.001), but a lower score for relationship with family than survivors (p &lt; 0.001). In adult siblings, Mental Component Summary score was lower than general population (p &lt; 0.001). Level of siblings&#8217; QoL was linked with female gender, but no association was found with cancer-related factors. <strong>Conclusion<\/strong>: Brothers and sisters expressed a divergent perception of their long-term QoL depending on their age. To minimize the impact from childhood to adulthood, long-term attention should also be paid to siblings, often referred as &#8220;forgotten children&#8221;.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cindy Faust,\u00a0Pascal Auquier,\u00a0Zeinab Hamidou,\u00a0Yves Bertrand,\u00a0Marie-Dominique Tabone,\u00a0Sophie Ansoborlo,\u00a0Andr\u00e9 Baruchel,\u00a0Virginie Gandemer,\u00a0Jean-Hugues Dalle,\u00a0Pascal Chastagner,\u00a0Justyna Kanold,\u00a0Maryline Poir\u00e9e,\u00a0Nicolas Sirvent,\u00a0Genevi\u00e8ve Plat,\u00a0Isabelle Pellier,\u00a0G\u00e9rard Michel , Julie Berbis [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[8,67,11,26,68],"class_list":["post-5534","publications_science","type-publications_science","status-publish","hentry","keywords-scientifique-publication-childhood-leukemia","keywords-long-term-follow-up","keywords-quality-of-life-in-childhood-cancer-cohort","keywords-siblings-in-childhood-leukemia","keywords-survivors"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>35. 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Brothers and sisters of childhood acute leukemia survivors: Their long-term quality of life and its determinants - Lea\" \/>\n<meta property=\"og:description\" content=\"Cindy Faust,\u00a0Pascal Auquier,\u00a0Zeinab Hamidou,\u00a0Yves Bertrand,\u00a0Marie-Dominique Tabone,\u00a0Sophie Ansoborlo,\u00a0Andr\u00e9 Baruchel,\u00a0Virginie Gandemer,\u00a0Jean-Hugues Dalle,\u00a0Pascal Chastagner,\u00a0Justyna Kanold,\u00a0Maryline Poir\u00e9e,\u00a0Nicolas Sirvent,\u00a0Genevi\u00e8ve Plat,\u00a0Isabelle Pellier,\u00a0G\u00e9rard Michel , Julie Berbis [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/\" \/>\n<meta property=\"og:site_name\" content=\"Lea\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/\",\"name\":\"35. 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Brothers and sisters of childhood acute leukemia survivors: Their long-term quality of life and its determinants - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/","og_locale":"en_US","og_type":"article","og_title":"35. Brothers and sisters of childhood acute leukemia survivors: Their long-term quality of life and its determinants - Lea","og_description":"Cindy Faust,\u00a0Pascal Auquier,\u00a0Zeinab Hamidou,\u00a0Yves Bertrand,\u00a0Marie-Dominique Tabone,\u00a0Sophie Ansoborlo,\u00a0Andr\u00e9 Baruchel,\u00a0Virginie Gandemer,\u00a0Jean-Hugues Dalle,\u00a0Pascal Chastagner,\u00a0Justyna Kanold,\u00a0Maryline Poir\u00e9e,\u00a0Nicolas Sirvent,\u00a0Genevi\u00e8ve Plat,\u00a0Isabelle Pellier,\u00a0G\u00e9rard Michel , Julie Berbis [&hellip;]","og_url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/","og_site_name":"Lea","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/","url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/35-brothers-and-sisters-of-childhood-acute-leukemia-survivors-their-long-term-quality-of-life-and-its-determinants\/","name":"35. 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