{"id":304,"date":"2011-08-11T20:56:11","date_gmt":"2011-08-11T18:56:11","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=304"},"modified":"2021-03-02T15:21:03","modified_gmt":"2021-03-02T14:21:03","slug":"bone-mineral-density-in-adult-survivors-of-childhood-acute-leukemia-impact-of-hematopoietic-stem-cell-transplantation-and-other-treatment-modalities","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/bone-mineral-density-in-adult-survivors-of-childhood-acute-leukemia-impact-of-hematopoietic-stem-cell-transplantation-and-other-treatment-modalities\/","title":{"rendered":"5. Bone mineral density in adult-survivors of childhood acute leukemia: impact of hematopoietic stem cell transplantation and other treatment modalities."},"content":{"rendered":"<h3>Marion\u00a0 Le\u00a0 Meignen,\u00a0 Pascal\u00a0 Auquier,\u00a0 Vincent\u00a0 Barlogis,\u00a0 Nicolas\u00a0 Sirvent,\u00a0 Audrey\u00a0 Contet,\u00a0\u00a0 Marie-Claude\u00a0\u00a0 Simeoni,\u00a0\u00a0 Claire Galambrun, Marilyne\u00a0\u00a0 Poir\u00e9e,\u00a0\u00a0 Pascal\u00a0\u00a0 Chastagner, Barbara\u00a0 Play,\u00a0 Virginie\u00a0 Villes, Julie\u00a0 Berbis,\u00a0 Herv\u00e9\u00a0 Chambost,\u00a0 Pierre\u00a0 Bordigoni and G\u00e9rard Michel.<\/h3>\n<h3>Blood.\u00a02011 Aug 11;118(6):1481-9.<\/h3>\n<p><strong><a style=\"color: #6697ff; transition-timing-function: ease-in; outline: 0px;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21596857\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21596857\/<\/a><\/strong><\/p>\n<p>Femoral and lumbar bone mineral densities (BMDs) were measured in 159 adults enrolled in the Leuc\u00e9mies de l&#8217;Enfant et de l&#8217;Adolescent program, a French prospective multicentric cohort of childhood leukemia survivors. BMDs were expressed as Z-scores, and multivariate linear regression analyses were used to construct association models with potential risk factors. Mean age at evaluation and follow-up was 23 and 14.7 years, respectively. In the whole cohort, mean femoral Z-score was -0.19 \u00b1 0.08. Two factors were associated with lower femoral BMD transplantation (-0.49 \u00b1 0.15 vs -0.04 \u00b1 0.10 in the chemotherapy group; P = .006) and female sex (-0.34 \u00b1 0.10 vs -0.03 \u00b1 0.13; P = .03). Among patients who received a transplant, the only significant risk factor was hypogonadism (-0.88 \u00b1 0.16 vs -0.10 \u00b1 0.23; P = .04). A slight reduction in lumbar BMD (mean Z-score, -0.37 \u00b1 0.08) was detected in the whole cohort without difference between the transplantation and chemotherapy groups. Among patients who received a transplant, younger age at transplantation was correlated with a low lumbar BMD (P = .03). We conclude that adults who had received only chemotherapy for childhood leukemia have a slight reduction in their lumbar BMD and a normal femoral BMD. Patients who received a transplant with gonadal deficiency have a reduced femoral BMD which might increase the fracture risk later in life.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Marion\u00a0 Le\u00a0 Meignen,\u00a0 Pascal\u00a0 Auquier,\u00a0 Vincent\u00a0 Barlogis,\u00a0 Nicolas\u00a0 Sirvent,\u00a0 Audrey\u00a0 Contet,\u00a0\u00a0 Marie-Claude\u00a0\u00a0 Simeoni,\u00a0\u00a0 Claire Galambrun, Marilyne\u00a0\u00a0 Poir\u00e9e,\u00a0\u00a0 Pascal\u00a0\u00a0 Chastagner, Barbara\u00a0 [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[42,43],"class_list":["post-304","publications_science","type-publications_science","status-publish","hentry","keywords-bone-mineral-density-childhood-leukemia","keywords-hematopoietic-stem-cell-transplantation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>5. 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