{"id":302,"date":"2011-04-28T20:54:10","date_gmt":"2011-04-28T18:54:10","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=302"},"modified":"2021-03-02T15:20:15","modified_gmt":"2021-03-02T14:20:15","slug":"prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/","title":{"rendered":"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia."},"content":{"rendered":"<h3>Claire\u00a0 Oudin,\u00a0 Marie-Claude\u00a0 Simeoni,\u00a0 Nicolas\u00a0 Sirvent,\u00a0 Audrey\u00a0 Contet,\u00a0 Audrey\u00a0 Begu-Le\u00a0 Coroller,\u00a0 Pierre\u00a0 Bordigoni,\u00a0 Catherine\u00a0 Curtillet,\u00a0 Maryline\u00a0 Poir\u00e9e,\u00a0 Isabelle\u00a0 Thuret,\u00a0\u00a0 Barbara\u00a0\u00a0 Play,\u00a0\u00a0 Mara\u00a0\u00a0 Carazza\u00a0\u00a0 Massot,\u00a0\u00a0 Pascal\u00a0\u00a0 Chastagner,\u00a0\u00a0 Herv\u00e9\u00a0\u00a0 Chambost, Pascal Auquier and G\u00e9rard Michel.<\/h3>\n<h3>Blood.\u00a02011 Apr 28;117(17):4442-8.<\/h3>\n<p><a style=\"color: #6697ff; transition-timing-function: ease-in; outline: 0px;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21278355\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21278355\/<\/a><\/p>\n<p>We evaluate the prevalence and risk factors of the metabolic syndrome (MS) in young adults surviving childhood leukemia. During the years 2007 to 2008, assessment of MS was proposed to all adults included in the Leuc\u00e9mie de l&#8217;Enfant et de l&#8217;Adolescent program, a French prospective multicentric cohort of leukemia survivors. Among 220 eligible patients, 184 (83.6%) had complete evaluation. Median age at evaluation and follow-up duration were 21.2 and 15.4 years. Overall prevalence of MS was 9.2% (95% confidence interval, 5.5-14.4).<\/p>\n<p>There was no association of MS with sex, age at diagnosis, leukemia subtype, steroid therapy, and central nervous system irradiation. Patients were stratified according to 4 therapeutic modalities: chemotherapy alone (n = 97), chemotherapy and central nervous system irradiation (n = 27), hematopoietic stem cell transplantation (HSCT) without (n = 17) or with (n = 43) total body irradiation (TBI). MS occurred in 5.2%, 11.1%, 5.9%, and 18.6% of them, respectively.<\/p>\n<p>The higher risk observed in the HSCT-TBI group was significant in univariate and in multivariate analysis (odds ratio [OR] = 3.9, P = .03). HSCT with TBI was associated with a higher rate of hypertriglyceridemia (OR = 4.5, P = .004), low level of high-density lipoprotein cholesterol (OR = 2.5, P = .02), and elevated fasting glucose (OR = 6.1, P = .04) So, TBI is a major risk factor for MS. Further studies are warranted to explain this feature.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Claire\u00a0 Oudin,\u00a0 Marie-Claude\u00a0 Simeoni,\u00a0 Nicolas\u00a0 Sirvent,\u00a0 Audrey\u00a0 Contet,\u00a0 Audrey\u00a0 Begu-Le\u00a0 Coroller,\u00a0 Pierre\u00a0 Bordigoni,\u00a0 Catherine\u00a0 Curtillet,\u00a0 Maryline\u00a0 Poir\u00e9e,\u00a0 Isabelle\u00a0 Thuret,\u00a0\u00a0 Barbara\u00a0\u00a0 [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[43,28,19],"class_list":["post-302","publications_science","type-publications_science","status-publish","hentry","keywords-hematopoietic-stem-cell-transplantation","keywords-iron-overload-in-hematological-malignancies","keywords-metabolic-syndrome-in-hematological-malignancies"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. - Lea\" \/>\n<meta property=\"og:description\" content=\"Claire\u00a0 Oudin,\u00a0 Marie-Claude\u00a0 Simeoni,\u00a0 Nicolas\u00a0 Sirvent,\u00a0 Audrey\u00a0 Contet,\u00a0 Audrey\u00a0 Begu-Le\u00a0 Coroller,\u00a0 Pierre\u00a0 Bordigoni,\u00a0 Catherine\u00a0 Curtillet,\u00a0 Maryline\u00a0 Poir\u00e9e,\u00a0 Isabelle\u00a0 Thuret,\u00a0\u00a0 Barbara\u00a0\u00a0 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/\" \/>\n<meta property=\"og:site_name\" content=\"Lea\" \/>\n<meta property=\"article:modified_time\" content=\"2021-03-02T14:20:15+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/\",\"name\":\"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. - Lea\",\"isPartOf\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\"},\"datePublished\":\"2011-04-28T18:54:10+00:00\",\"dateModified\":\"2021-03-02T14:20:15+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientific publications\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"name\":\"Lea\",\"description\":\"Malignant haemopathies in children and adolescents\",\"publisher\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\",\"name\":\"Plateforme LEA\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"contentUrl\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"width\":600,\"height\":260,\"caption\":\"Plateforme LEA\"},\"image\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/","og_locale":"en_US","og_type":"article","og_title":"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. - Lea","og_description":"Claire\u00a0 Oudin,\u00a0 Marie-Claude\u00a0 Simeoni,\u00a0 Nicolas\u00a0 Sirvent,\u00a0 Audrey\u00a0 Contet,\u00a0 Audrey\u00a0 Begu-Le\u00a0 Coroller,\u00a0 Pierre\u00a0 Bordigoni,\u00a0 Catherine\u00a0 Curtillet,\u00a0 Maryline\u00a0 Poir\u00e9e,\u00a0 Isabelle\u00a0 Thuret,\u00a0\u00a0 Barbara\u00a0\u00a0 [&hellip;]","og_url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/","og_site_name":"Lea","article_modified_time":"2021-03-02T14:20:15+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/","url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/","name":"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. - Lea","isPartOf":{"@id":"https:\/\/plateforme-lea.fr\/en\/#website"},"datePublished":"2011-04-28T18:54:10+00:00","dateModified":"2021-03-02T14:20:15+00:00","breadcrumb":{"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/prevalence-and-risk-factors-of-the-metabolic-syndrome-in-adult-survivors-of-childhood-leukemia\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/plateforme-lea.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Scientific publications","item":"https:\/\/plateforme-lea.fr\/en\/publications_science\/"},{"@type":"ListItem","position":3,"name":"3. Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia."}]},{"@type":"WebSite","@id":"https:\/\/plateforme-lea.fr\/en\/#website","url":"https:\/\/plateforme-lea.fr\/en\/","name":"Lea","description":"Malignant haemopathies in children and adolescents","publisher":{"@id":"https:\/\/plateforme-lea.fr\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/plateforme-lea.fr\/en\/#organization","name":"Plateforme LEA","url":"https:\/\/plateforme-lea.fr\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/","url":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","contentUrl":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","width":600,"height":260,"caption":"Plateforme LEA"},"image":{"@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science"}],"about":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/types\/publications_science"}],"version-history":[{"count":0,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/302\/revisions"}],"wp:attachment":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/media?parent=302"}],"wp:term":[{"taxonomy":"keywords","embeddable":true,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/keywords?post=302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}