https:\/\/pubmed.ncbi.nlm.nih.gov\/21725370\/<\/a><\/p>\nThe literature contains a substantial amount of information about factors that adversely influence the linear growth in up to 85% of patients undergoing haematopoietic SCT (HSCT) with TBI and\/or cranial irradiation (CI) for acute leukaemia (AL). By contrast, only a few studies have evaluated the impact of growth hormone (GH) therapy on growth rate and final height (FH) in these children. We evaluated growth rates during the pre- and post-transplant periods to FH in a group of 25 children treated with HSCT (n=22), TBI (n=21) or\/and CI (n=8) for AL and receiving GH therapy.<\/p>\n
At the start of GH treatment, the median height Z-score was -2.19 (-3.95 to 0.02), significantly lower than at AL diagnosis (P<0.001). Overall height gain from start of GH treatment to FH was 0.59Z (-2.72 to 2.93) with a median height Z-score at FH of -1.35 (-5.35 to 0.27). This overall height gain effect was greater in girls than in boys (P=0.04). The number of children with heights in the reference population range was greater after than before GH therapy (P=0.07). At FH the GVHD and GH treatments lasting <2 years were associated with shorter FH (P=0.02 and 0.05).<\/p>\n
We found a measurable beneficial effect of GH treatment on growth up to FH.<\/p>\n","protected":false},"excerpt":{"rendered":"
Florentina Isfan, Justyna Kanold, Etienne Merlin, Audrey Contet, Nicolas Sirvent, Emmanuelle Rochette, Marilyne Poir\u00e9e, Daniel Terral, H\u00e9l\u00e8ne Carla-Malpuech, Rachel Reynaud, […]<\/p>\n","protected":false},"template":"","keywords":[37,43,28],"class_list":["post-298","publications_science","type-publications_science","status-publish","hentry","keywords-growth-hormone-childhood-cancer-cohort","keywords-hematopoietic-stem-cell-transplantation","keywords-iron-overload-in-hematological-malignancies"],"acf":[],"yoast_head":"\n
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