{"id":284,"date":"2015-03-01T20:38:31","date_gmt":"2015-03-01T19:38:31","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=284"},"modified":"2021-03-01T16:01:19","modified_gmt":"2021-03-01T15:01:19","slug":"health-status-and-quality-of-life-of-long-term-survivors-of-childhood-acute-leukemia-the-impact-of-central-nervous-system-irradiation","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/health-status-and-quality-of-life-of-long-term-survivors-of-childhood-acute-leukemia-the-impact-of-central-nervous-system-irradiation\/","title":{"rendered":"15. Health status and quality of life of long-term survivors of childhood acute leukemia: the impact of central nervous system irradiation."},"content":{"rendered":"<h3>Joy Benadiba, G\u00e9rard Michel, Pascal Auquier, Pascal Chastagner, Justyna Kanold, Maryline Poir\u00e9e, Dominique Plantaz, Laetitia Padovani, Julie Berbis, Vincent Barlogis, Audrey Contet, Herv\u00e9 Chambost and Nicolas Sirvent.<\/h3>\n<h3>J Pediatr Hematol Oncol.\u00a02015 Mar;37(2):109-16.<\/h3>\n<p><a style=\"color: #6697ff; transition-timing-function: ease-in; outline: 0px;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24936742\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24936742\/<\/a><\/p>\n<p>We evaluated the impact of central nervous system irradiation (CNSI) on long-term health status and quality of life (QoL) of childhood lymphoblastic leukemia survivors included in the French L.E.A. (Childhood and Adolescent Leukemia) multicentric cohort. QoL was self-reported in adults and assessed by parents in children and adolescents, using adapted questionnaires. From 2004 to 2009, 630 nongrafted patients were assessed after 11.8\u00b16.3 years from diagnosis.<\/p>\n<p>Patients receiving CNSI (18.6%) or chemotherapy alone (81.4%) were compared. The risk of having long-term physical effects was increased with CNSI (odds ratio=3.3; 95% confidence interval, 1.8-5.9), especially regarding growth failure, second tumor, cataract, and overweight. QoL did not differ significantly according to the treatment received, despite a tendency toward lower scores with CNSI in children and adolescents (summary score 63.6\u00b113.3 vs. 71.7\u00b112.4, P=0.14).<\/p>\n<p>Compared with French norms, adult survivors had an impaired QoL, especially in mental domains (mental composite score 45.2\u00b19.8 vs. 47.9\u00b12.1, P&lt;0.001). In pediatric survivors, QoL was not impaired and even tended to be higher than population norms (summary score 71.7\u00b112.4 vs. 70.0\u00b14.2, P=0.054), mainly in social and relational domains.<\/p>\n<p>In conclusion, QoL seems to be impaired by the trauma of a life-threatening illness in childhood, as well as by the treatment received.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Joy Benadiba, G\u00e9rard Michel, Pascal Auquier, Pascal Chastagner, Justyna Kanold, Maryline Poir\u00e9e, Dominique Plantaz, Laetitia Padovani, Julie Berbis, Vincent Barlogis, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[51,43,28,11],"class_list":["post-284","publications_science","type-publications_science","status-publish","hentry","keywords-chemotherapy-childhood-leukemia","keywords-hematopoietic-stem-cell-transplantation","keywords-iron-overload-in-hematological-malignancies","keywords-quality-of-life-in-childhood-cancer-cohort"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>15. 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Health status and quality of life of long-term survivors of childhood acute leukemia: the impact of central nervous system irradiation. - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/health-status-and-quality-of-life-of-long-term-survivors-of-childhood-acute-leukemia-the-impact-of-central-nervous-system-irradiation\/","og_locale":"en_US","og_type":"article","og_title":"15. 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