{"id":266,"date":"2016-11-01T20:22:06","date_gmt":"2016-11-01T19:22:06","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&p=266"},"modified":"2021-03-01T15:51:29","modified_gmt":"2021-03-01T14:51:29","slug":"the-impact-of-donor-type-on-long-term-health-status-and-quality-of-life-after-allogeneic-hematopoietic-stem-cell-transplantation-for-childhood-acute-leukemia-a-leucemie-de-lenfant-et-de-l","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/the-impact-of-donor-type-on-long-term-health-status-and-quality-of-life-after-allogeneic-hematopoietic-stem-cell-transplantation-for-childhood-acute-leukemia-a-leucemie-de-lenfant-et-de-l\/","title":{"rendered":"23. The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leuc\u00e9mie de l\u2019Enfant et de L\u2019Adolescent Study."},"content":{"rendered":"

Sandrine Visentin, Pascal Auquier, Yves Bertrand, Andr\u00e9 Baruchel, Marie-Dominique Tabone, C\u00e9cile Pochon, Charlotte Jubert, Maryline Poir\u00e9e, Virginie Gandemer, Anne Sirvent, Jacinthe Bonneau, Catherine Paillard, Claire Freycon, Justyna Kanold, Virginie Villes, Julie Berbis, Claire Oudin, Claire Galambrun, Isabelle Pellier, Genevi\u00e8ve Plat, Herv\u00e9 Chambost, Guy Leverger, Jean-Hugues Dalle and G\u00e9rard Michel.<\/h3>\n

Biol Blood Marrow Transplant.\u00a02016 Nov;22(11):2003-2010.<\/h3>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/27522039\/<\/a><\/h3>\n

We compared the long-term impact of donor type (sibling donor [SD] versus matched unrelated donor [MUD] or umbilical cord blood [UCB]) on late side effects and quality of life (QoL) in childhood acute leukemia sur-vivors treated with hematopoietic stem cell transplantation. We included 314 patients who underwenttransplantation from 1997 to 2012 and were enrolled in the multicenter French Leuc\u00e9mie de l\u2019Enfant et deL\u2019Adolescent (\u201cLeukemia in Children and Adolescents\u201d) cohort. More than one-third of the patients were adultsat last visit; mean follow-up duration was 6.2 years. At least 1 late effect was observed in 284 of 314 patients(90.4%).<\/p>\n

The average number of adverse late effects was 2.1\u00b1.1, 2.4\u00b1.2, and 2.4\u00b1.2 after SD, MUD, and UCBtransplantation, respectively. In a multivariate analysis, considering the SD group as the reference, we did notdetect an impact of donor type for most sequelae, with the exception of increased risk of major growth failureafter MUD transplantation (odds ratio [OR], 2.42) and elevated risk of osteonecrosis after UCB transplanta-tion (OR, 4.15).<\/p>\n

The adults and children\u2019s parents reported comparable QoL among the 3 groups. Adult patientQoL scores were lower than age- and sex-matched French reference scores for almost all dimensions. We con-clude that although these patients are heavily burdened by long-term complications, donor type had a verylimited impact on their long-term health status and QoL.<\/p>\n","protected":false},"excerpt":{"rendered":"

Sandrine Visentin, Pascal Auquier, Yves Bertrand, Andr\u00e9 Baruchel, Marie-Dominique Tabone, C\u00e9cile Pochon, Charlotte Jubert, Maryline Poir\u00e9e, Virginie Gandemer, Anne Sirvent, […]<\/p>\n","protected":false},"template":"","keywords":[43,20,46],"class_list":["post-266","publications_science","type-publications_science","status-publish","hentry","keywords-hematopoietic-stem-cell-transplantation","keywords-late-effects-in-hematological-malignancies","keywords-sibling-donor-in-childhood-leukemia"],"acf":[],"yoast_head":"\n23. The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leuc\u00e9mie de l\u2019Enfant et de L\u2019Adolescent Study. - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/the-impact-of-donor-type-on-long-term-health-status-and-quality-of-life-after-allogeneic-hematopoietic-stem-cell-transplantation-for-childhood-acute-leukemia-a-leucemie-de-lenfant-et-de-l\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"23. 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