{"id":264,"date":"2016-12-01T20:20:21","date_gmt":"2016-12-01T19:20:21","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&p=264"},"modified":"2021-03-01T15:50:39","modified_gmt":"2021-03-01T14:50:39","slug":"metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/","title":{"rendered":"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study."},"content":{"rendered":"

Paul Saultier, Pascal Auquier, Yves Bertrand, Camille Vercasson, Claire Oudin, Audrey Contet, Dominique Plantaz, Marilyne Poir\u00e9e, St\u00e9phane Ducassou, Justyna Kanold,Marie-Dominique Tabone, Jean-Hugues Dalle, Patrick Lutz, Virginie Gandemer, Nicolas Sirvent, Sandrine Thouvenin, Julie Berbis, Herv\u00e9 Chambost, Andr\u00e9 Baruchel, Guy Leverger, and G\u00e9rard Michel.<\/h3>\n

Haematologica. 2016 Dec;101(12):1603-1610.<\/h3>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/27515247\/<\/a><\/h3>\n

Cardiovascular conditions are serious long-term complications of childhood acute leukemia. However, few studies have investigated the risk of metabolic syndrome, a known predictor of cardiovascular disease, in patients treated without hematopoietic stem cell transplantation. We describe the overall and age-specific prevalence, and the risk factors for metabolic syndrome and its components in the L.E.A. (Leuc\u00e9mie de l’Enfant et de l’Adolescent) French cohort of childhood acute leukemia survivors treated without hematopoietic stem cell transplantation. The study included 650 adult patients (mean age at evaluation: 24.2 years; mean follow-up after leukemia diagnosis: 16.0 years). The prevalence of metabolic syndrome was 6.9% (95% CI 5.1-9.2). The age-specific cumulative prevalence at 20, 25, 30 and 35 years of age was 1.3%, 6.1%, 10.8% and 22.4%, respectively.<\/p>\n

The prevalence of decreased high-density lipoprotein cholesterol, increased triglycerides, increased fasting glucose, increased blood pressure and increased abdominal circumference was 26.8%, 11.7%, 5.8%, 36.7% and 16.7%, respectively. Risk factors significantly associated with metabolic syndrome in the multivariate analysis were male sex (OR 2.64; 95% CI 1.32-5.29), age at last evaluation (OR 1.10; 95% CI 1.04-1.17) and body mass index at diagnosis (OR 1.15; 95% CI 1.01-1.32).<\/p>\n

The cumulative steroid dose was not a significant risk factor. Irradiated and non-irradiated patients exhibited different patterns of metabolic abnormalities, with more frequent abdominal obesity in irradiated patients and more frequent hypertension in non-irradiated patients. Survivors of childhood acute leukemia are at risk of metabolic syndrome, even when treated without hematopoietic stem cell transplantation or central nervous system irradiation.<\/p>\n

A preventive approach with regular screening for cardiovascular risk factors is recommended.<\/p>\n","protected":false},"excerpt":{"rendered":"

Paul Saultier, Pascal Auquier, Yves Bertrand, Camille Vercasson, Claire Oudin, Audrey Contet, Dominique Plantaz, Marilyne Poir\u00e9e, St\u00e9phane Ducassou, Justyna Kanold,Marie-Dominique […]<\/p>\n","protected":false},"template":"","keywords":[56,43,28,19],"class_list":["post-264","publications_science","type-publications_science","status-publish","hentry","keywords-cardiovascular-disease-childhood-leukemia","keywords-hematopoietic-stem-cell-transplantation","keywords-iron-overload-in-hematological-malignancies","keywords-metabolic-syndrome-in-hematological-malignancies"],"acf":[],"yoast_head":"\n25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study. - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study. - Lea\" \/>\n<meta property=\"og:description\" content=\"Paul Saultier, Pascal Auquier, Yves Bertrand, Camille Vercasson, Claire Oudin, Audrey Contet, Dominique Plantaz, Marilyne Poir\u00e9e, St\u00e9phane Ducassou, Justyna Kanold,Marie-Dominique […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Lea\" \/>\n<meta property=\"article:modified_time\" content=\"2021-03-01T14:50:39+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/\",\"name\":\"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study. - Lea\",\"isPartOf\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\"},\"datePublished\":\"2016-12-01T19:20:21+00:00\",\"dateModified\":\"2021-03-01T14:50:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientific publications\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"name\":\"Lea\",\"description\":\"Malignant haemopathies in children and adolescents\",\"publisher\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\",\"name\":\"Plateforme LEA\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"contentUrl\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"width\":600,\"height\":260,\"caption\":\"Plateforme LEA\"},\"image\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study. - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/","og_locale":"en_US","og_type":"article","og_title":"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study. - Lea","og_description":"Paul Saultier, Pascal Auquier, Yves Bertrand, Camille Vercasson, Claire Oudin, Audrey Contet, Dominique Plantaz, Marilyne Poir\u00e9e, St\u00e9phane Ducassou, Justyna Kanold,Marie-Dominique […]","og_url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/","og_site_name":"Lea","article_modified_time":"2021-03-01T14:50:39+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/","url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/","name":"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study. - Lea","isPartOf":{"@id":"https:\/\/plateforme-lea.fr\/en\/#website"},"datePublished":"2016-12-01T19:20:21+00:00","dateModified":"2021-03-01T14:50:39+00:00","breadcrumb":{"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/metabolic-syndrome-in-long-term-survivors-of-childhood-acute-leukemia-treated-without-hematopoietic-stem-cell-transplantation-an-l-e-a-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/plateforme-lea.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Scientific publications","item":"https:\/\/plateforme-lea.fr\/en\/publications_science\/"},{"@type":"ListItem","position":3,"name":"25. Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study."}]},{"@type":"WebSite","@id":"https:\/\/plateforme-lea.fr\/en\/#website","url":"https:\/\/plateforme-lea.fr\/en\/","name":"Lea","description":"Malignant haemopathies in children and adolescents","publisher":{"@id":"https:\/\/plateforme-lea.fr\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/plateforme-lea.fr\/en\/#organization","name":"Plateforme LEA","url":"https:\/\/plateforme-lea.fr\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/","url":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","contentUrl":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","width":600,"height":260,"caption":"Plateforme LEA"},"image":{"@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science"}],"about":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/types\/publications_science"}],"version-history":[{"count":0,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/264\/revisions"}],"wp:attachment":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/media?parent=264"}],"wp:term":[{"taxonomy":"keywords","embeddable":true,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/keywords?post=264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}