https:\/\/pubmed.ncbi.nlm.nih.gov\/29351982\/<\/a><\/p>\nThe prevalence of the metabolic syndrome among adults from the French LEA childhood acute leukemia survivors’ cohort was prospectively evaluated considering the type of anti-leukemic treatment received, and compared with that of controls. The metabolic profile of these patients was compared with that of controls. A total of 3203 patients from a French volunteer cohort were age- and sex-matched 3:1 to 1025 leukemia survivors (in both cohorts, mean age: 24.4 years; females: 51%). Metabolic syndrome was defined according to the National Cholesterol Education Program’s Adult Treatment Panel III criteria. Metabolic syndrome was found in 10.3% of patients (mean follow-up duration: 16.3\u00b10.2 years) and 4.5% of controls, (OR=2.49; P<0.001).<\/p>\n
Patients transplanted with total body irradiation presented the highest risk (OR=6.26; P<0.001); the other treatment groups also showed a higher risk than controls, including patients treated with chemotherapy only. Odd Ratios were 1.68 (P=0.005) after chemotherapy only, 2.32 (P=0.002) after chemotherapy and cranial irradiation, and 2.18 (P=0.057) in patients transplanted without irradiation. Total body irradiation recipients with metabolic syndrome displayed a unique profile compared with controls: smaller waist circumference (91 vs 99.6 cm; P=0.01), and increased triglyceride levels (3.99 vs 1.5 mmol\/L; P<0.001), fasting glucose levels (6.2 vs 5.6 mmol\/L; P=0.049), and systolic blood pressure (137.9 vs 132.8 mmHg; P=0.005).<\/p>\n
By contrast, cranial irradiation recipients with metabolic syndrome had a larger waist circumference (109 vs 99.6 cm; P=0.007) than controls. Regardless of the anti-leukemic treatment, metabolic syndrome risk was higher among childhood leukemia survivors. Its presentation differed depending on the treatment type, thus suggesting a divergent pathophysiology.<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Claire Oudin, Julie Berbis, Yves Bertrand, Camille Vercasson, Fr\u00e9d\u00e9rique Thomas, Pascal Chastagner, St\u00e9phane Ducassou, Justyna Kanold, Marie-Dominique Tabone, Catherine Paillard, […]<\/p>\n","protected":false},"template":"","keywords":[51,43,28,19],"class_list":["post-249","publications_science","type-publications_science","status-publish","hentry","keywords-chemotherapy-childhood-leukemia","keywords-hematopoietic-stem-cell-transplantation","keywords-iron-overload-in-hematological-malignancies","keywords-metabolic-syndrome-in-hematological-malignancies"],"acf":[],"yoast_head":"\n
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