{"id":245,"date":"2019-04-01T18:43:27","date_gmt":"2019-04-01T16:43:27","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=245"},"modified":"2021-03-01T15:25:52","modified_gmt":"2021-03-01T14:25:52","slug":"lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/","title":{"rendered":"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia."},"content":{"rendered":"<h3>Sandrine Visentin, G\u00e9rard Michel, Claire Oudin, B\u00e9atrice Cousin, B\u00e9n\u00e9dicte Gaborit, In\u00e8s Abdesselam, Marie Maraninchi, Marion Nowicki, Ren\u00e9 Val\u00e9ro, Maxime Guye, Monique Bernard, Pascal Auquier, Herv\u00e9 Chambost, Marie-Christine Alessi and Sophie B\u00e9liard.<\/h3>\n<h3>Endocrine connections. 2019 Apr;8(4):349-359.<\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30844749\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30844749\/<\/a><\/p>\n<h2>Background\/objective<\/h2>\n<p>The number of long-term survivors of childhood acute leukemia (AL) is substantially growing. These patients are at high risk for metabolic syndrome (MS), especially those who received total body irradiation (TBI). The consequences of children\u2019s irradiation on adipose tissue (AT) development in adulthood are currently unknown. The objective of this study is to assess the impact of TBI on AT of childhood AL survivors.<\/p>\n<h2>Design<\/h2>\n<p>We compared the morphological and functional characteristics of AT among survivors of childhood AL who developed MS and received (n = 12) or not received (n = 12) TBI.<\/p>\n<h2>Subjects\/methods<\/h2>\n<p>Body fat distribution and ectopic fat stores (abdominal visceral and liver fat) were evaluated by DEXA, MRI and 1H-spectroscopy. Functional characteristics of subcutaneous AT were investigated by studying gene expression and pre-adipocyte differentiation in culture.<\/p>\n<h2>Results<\/h2>\n<p>Patients who have received TBI exhibited a lower BMI (minus 5 kg\/m2) and a lower waist circumference (minus 14 cm), especially irradiated women. Despite the lower quantity of intra-abdominal AT, irradiated patient displayed a nearly two-fold greater content of liver fat when compared to non-irradiated patient (17 vs 9%, P = 0.008). These lipodystrophic-like features are supplemented by molecular abnormalities in subcutaneous AT of irradiated patients: decrease of gene expression of SREBP1 (minus 39%, P = 0.01) and CIDEA (minus 36%, P = 0.004) and a clear alteration of pre-adipocyte differentiation.<\/p>\n<h2>Conclusions<\/h2>\n<p>These results strongly support the direct effect of irradiation on AT, especially in women, leading to specific nonalcoholic fatty liver disease, despite lower BMI. A long-term appropriate follow-up is necessary for these patients.<\/p>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>adipocytes; childhood AL; ectopic fat; hepatic steatosis; irradiation; metabolic syndrome.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sandrine Visentin, G\u00e9rard Michel, Claire Oudin, B\u00e9atrice Cousin, B\u00e9n\u00e9dicte Gaborit, In\u00e8s Abdesselam, Marie Maraninchi, Marion Nowicki, Ren\u00e9 Val\u00e9ro, Maxime Guye, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[48,28,19],"class_list":["post-245","publications_science","type-publications_science","status-publish","hentry","keywords-adipocytes-in-childhood-leukemia","keywords-iron-overload-in-hematological-malignancies","keywords-metabolic-syndrome-in-hematological-malignancies"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. - Lea\" \/>\n<meta property=\"og:description\" content=\"Sandrine Visentin, G\u00e9rard Michel, Claire Oudin, B\u00e9atrice Cousin, B\u00e9n\u00e9dicte Gaborit, In\u00e8s Abdesselam, Marie Maraninchi, Marion Nowicki, Ren\u00e9 Val\u00e9ro, Maxime Guye, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/\" \/>\n<meta property=\"og:site_name\" content=\"Lea\" \/>\n<meta property=\"article:modified_time\" content=\"2021-03-01T14:25:52+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/\",\"name\":\"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. - Lea\",\"isPartOf\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\"},\"datePublished\":\"2019-04-01T16:43:27+00:00\",\"dateModified\":\"2021-03-01T14:25:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientific publications\",\"item\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#website\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"name\":\"Lea\",\"description\":\"Malignant haemopathies in children and adolescents\",\"publisher\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#organization\",\"name\":\"Plateforme LEA\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"contentUrl\":\"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png\",\"width\":600,\"height\":260,\"caption\":\"Plateforme LEA\"},\"image\":{\"@id\":\"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/","og_locale":"en_US","og_type":"article","og_title":"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. - Lea","og_description":"Sandrine Visentin, G\u00e9rard Michel, Claire Oudin, B\u00e9atrice Cousin, B\u00e9n\u00e9dicte Gaborit, In\u00e8s Abdesselam, Marie Maraninchi, Marion Nowicki, Ren\u00e9 Val\u00e9ro, Maxime Guye, [&hellip;]","og_url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/","og_site_name":"Lea","article_modified_time":"2021-03-01T14:25:52+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/","url":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/","name":"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. - Lea","isPartOf":{"@id":"https:\/\/plateforme-lea.fr\/en\/#website"},"datePublished":"2019-04-01T16:43:27+00:00","dateModified":"2021-03-01T14:25:52+00:00","breadcrumb":{"@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/plateforme-lea.fr\/en\/publications_science\/lipodystrophy-like-features-after-total-body-irradiation-among-survivors-of-childhood-acute-leukemia\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/plateforme-lea.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Scientific publications","item":"https:\/\/plateforme-lea.fr\/en\/publications_science\/"},{"@type":"ListItem","position":3,"name":"31. Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia."}]},{"@type":"WebSite","@id":"https:\/\/plateforme-lea.fr\/en\/#website","url":"https:\/\/plateforme-lea.fr\/en\/","name":"Lea","description":"Malignant haemopathies in children and adolescents","publisher":{"@id":"https:\/\/plateforme-lea.fr\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/plateforme-lea.fr\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/plateforme-lea.fr\/en\/#organization","name":"Plateforme LEA","url":"https:\/\/plateforme-lea.fr\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/","url":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","contentUrl":"https:\/\/plateforme-lea.fr\/wp-content\/uploads\/2020\/12\/cropped-lea-logotype.png","width":600,"height":260,"caption":"Plateforme LEA"},"image":{"@id":"https:\/\/plateforme-lea.fr\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science"}],"about":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/types\/publications_science"}],"version-history":[{"count":0,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/publications_science\/245\/revisions"}],"wp:attachment":[{"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/media?parent=245"}],"wp:term":[{"taxonomy":"keywords","embeddable":true,"href":"https:\/\/plateforme-lea.fr\/en\/wp-json\/wp\/v2\/keywords?post=245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}