{"id":1603,"date":"2021-01-20T13:39:41","date_gmt":"2021-01-20T12:39:41","guid":{"rendered":"https:\/\/plateforme-lea.fr\/?post_type=publications_science&#038;p=1603"},"modified":"2021-03-01T15:24:41","modified_gmt":"2021-03-01T14:24:41","slug":"testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study","status":"publish","type":"publications_science","link":"https:\/\/plateforme-lea.fr\/en\/publications_science\/testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study\/","title":{"rendered":"33. Testosterone deficiency in men surviving childhood acute leukemia after treatment with hematopoietic stem cell transplantation or testicular radiation: an L.E.A. study"},"content":{"rendered":"<h3>Romain Lopez, Genevi\u00e8ve Plat, Yves Bertrand, St\u00e9phane Ducassou, Paul Saultier, Julie Berbis, Audrey Contet, Zeinab Hamidou, Marilyne Poir\u00e9e, Marie-Dominique Tabone, Justyna Kanold, Jean-Hugues Dalle, Virginie Gandemer, Catherine Paillard, Nicolas Sirvent, Dominique Plantaz, Sandrine Thouvenin, Isabelle Pellier, Sophie Ansoborlo, Guy Leverger, Andr\u00e9 Baruchel, Pascal Auquier and G\u00e9rard Michel.<\/h3>\n<h3>Bone Marrow Transplant. 2021 Jan 16.<span style=\"font-size: 1.25rem;\">\u00a0<\/span><span class=\"citation-doi\" style=\"font-size: 1.25rem;\">doi: 10.1038\/s41409-020-01180-y.<\/span><\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33454725\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33454725\/<\/a><\/p>\n<p>We included 255 patients from the L.E.A. French long-term follow-up cohort. All had received hematopoietic stem cell transplantation (HSCT) and\/or testicular radiation for childhood acute leukemia and were older than 18 years at last L.E.A. evaluation. Total testosterone deficiency was defined as a &lt;12 nmol\/l level or by substitutive therapy, partial deficiency as normal testosterone with elevated luteinizing hormone (&gt;10 UI\/l). After myeloablative total body irradiation (n = 178), 55.6% had total deficiency, 15.7% partial deficiency, and 28.7% were normal. A 4-6 Gy testicular boost and a younger age at HSCT increased significantly the risk. After a Busulfan-containing myeloablative conditioning regimen (n = 53), 28.3% had total deficiency, 15.1% partial deficiency, 56.6% were normal (62.5% vs. 0% in patients without or with additional testicular radiation). A 24-Gy testicular radiation without HSCT induced total or partial deficiency in 71.4% and 28.6%, respectively (n = 21). Total testosterone deficiency increased the risk of metabolic syndrome: 25% vs. 12.1% in men with partial testosterone deficiency and 8.8% when Leydig cell function was normal (p = 0.031).<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Romain Lopez, Genevi\u00e8ve Plat, Yves Bertrand, St\u00e9phane Ducassou, Paul Saultier, Julie Berbis, Audrey Contet, Zeinab Hamidou, Marilyne Poir\u00e9e, Marie-Dominique Tabone, [&hellip;]<\/p>\n","protected":false},"template":"","keywords":[43,19,45,44],"class_list":["post-1603","publications_science","type-publications_science","status-publish","hentry","keywords-hematopoietic-stem-cell-transplantation","keywords-metabolic-syndrome-in-hematological-malignancies","keywords-testicular-radiation-childhood-leukemia","keywords-testosterone-deficency-cancer-survivor"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>33. Testosterone deficiency in men surviving childhood acute leukemia after treatment with hematopoietic stem cell transplantation or testicular radiation: an L.E.A. study - Lea<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"33. Testosterone deficiency in men surviving childhood acute leukemia after treatment with hematopoietic stem cell transplantation or testicular radiation: an L.E.A. study - Lea\" \/>\n<meta property=\"og:description\" content=\"Romain Lopez, Genevi\u00e8ve Plat, Yves Bertrand, St\u00e9phane Ducassou, Paul Saultier, Julie Berbis, Audrey Contet, Zeinab Hamidou, Marilyne Poir\u00e9e, Marie-Dominique Tabone, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/plateforme-lea.fr\/en\/publications_science\/testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Lea\" \/>\n<meta property=\"article:modified_time\" content=\"2021-03-01T14:24:41+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study\/\",\"url\":\"https:\/\/plateforme-lea.fr\/en\/publications_science\/testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study\/\",\"name\":\"33. 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Testosterone deficiency in men surviving childhood acute leukemia after treatment with hematopoietic stem cell transplantation or testicular radiation: an L.E.A. study - Lea","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/plateforme-lea.fr\/en\/publications_science\/testosterone-deficiency-in-men-surviving-childhood-acute-leukemia-after-treatment-with-hematopoietic-stem-cell-transplantation-or-testicular-radiation-an-l-e-a-study\/","og_locale":"en_US","og_type":"article","og_title":"33. 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